正文

劉迎芳研究員

Yingfang?Liu,?Professor

中國科學(xué)院生物物理所 百人計(jì)劃，研究員

簡歷 & 研究組工作摘要：

1993-1999年:?畢業(yè)于北京大學(xué)植物分子生物學(xué)系研究生，獲博士學(xué)位

1999-2005年:?先后在美國國立猶太醫(yī)學(xué)研究中心免疫學(xué)系、冷泉港實(shí)驗(yàn)室以及杜克大學(xué)醫(yī)學(xué)中心從事博士后及研究助理工作

2005年至今：生物物理所研究組長，研究員

劉迎芳研究員于1999年在北京大學(xué)獲得理學(xué)博士學(xué)位。在美國的博士后研究期間，主要從事結(jié)構(gòu)生物學(xué)研究，對(duì)一些重要蛋白，例如SarA，SarR，TALL-1及其受體，進(jìn)行結(jié)構(gòu)和功能研究，取得多項(xiàng)重要研究成果。

2005年回國后加入生物物理所后主要從事于衰老與凋亡相關(guān)蛋白的結(jié)構(gòu)生物學(xué)研究工作。主要內(nèi)容為：1.凋亡細(xì)胞吞噬的分子機(jī)制研究。凋亡細(xì)胞的吞噬主要有兩條相互并行的通路介導(dǎo)，一是由CED-1,CED-6,CED-7和CED-14參與的信號(hào)途徑，另一個(gè)是由CED-2,CED-5,CED-12和CED-10介導(dǎo)。我們對(duì)這一通路相關(guān)蛋白開展結(jié)構(gòu)生物學(xué)研究工作，以期揭示這一重要通路中各分子的作用機(jī)制以及通路的調(diào)節(jié)機(jī)制。2.?癌癥相關(guān)蛋白、細(xì)胞衰老及凋亡過程中表觀遺傳學(xué)的結(jié)構(gòu)生物學(xué)研究。主要研究衰老及凋亡過程中染色體修飾的改變以及在基因表達(dá)調(diào)控中的作用，研究癌癥分子機(jī)制。3.?重大傳染病特別是流感病毒聚合酶結(jié)構(gòu)生物學(xué)研究等。

Biography & Introduction

September?1993-?May?1999:?Graduate?student,?Dept.?of?Plant?Molecular?Biology,?Peking?University,?P.R.?China.

August?1999-?February?2005:?Postdoctoral?Associate,?National?Jewish?Medical?and?Research?Center,?W.?M.?Keck?Structural?Biology?Laboratory,?Cold?Spring?Harbor?Laboratory?and?Duke?University?Medical?Center.

February?2005-present:?Principal?Investigator,?Institute?of?biophysics,?CAS.

Dr.?Yingfang?Liu?obtained?his?doctor?degree?on?Plant?Science?in?Peking?University,?1999.?In?his?postdoctoral?training?period?in?USA,?he?was?mainly?working?on?structure?biology?and?engaged?in?structural?and?functional?studies?of?some?very?important?proteins,?such?as?SarA,?SarR,?TALL-1?and?its?receptors?and?had?got?plenty?of?results.

Currently,?Liu’s?lab?is?mainly?working?on?structural?biology?studies?of?some?proteins?related?to?cancer,?aging?and?apoptosis.?Some?main?projects?are:?1.?Structural?and?functional?studies?of?proteins?involving?in?cell?corpse?engulfment.?Two?redundant?pathways?have?been?identified?for?cell?engulfment,?one?includes?CED-1,?CED-6,?CED-7?and?CED-14;?the?other?includes?CED-2,?CED-5,?CED-12?and?CED-10.?We?are?working?on?structural?studies?of?these?proteins?in?order?to?reveal?their?possible?roles?in?the?processes.?2.?Structural?study?of?epigenetic?modification?in?cancer,?aging?and?apoptosis?processes.?3.?Structural?and?functional?study?of?influenza?virus?polymerase.

Selected Publications：

Xiaojing?He,?Jie?Zhou,?Mark?Bartlam,?Rongguang?Zhang,?Jianyuan?Ma,?Zhiyong?Lou,?Xuemei?Li,?Jingjing?Li,?Andrzej?Joachimiak,?Zonghao?Zeng,?Ruowen?Ge,?Zihe?Rao*,?Yingfang?Liu*.?Crystal?structure?of?the?polymerase?PA_C:PB1_N?complex?from?an?avian?influenza?H5N1?virus.?Nature,?July?9,2008?(on-line).?(*?Correspondence)

Yang?XY,?Zhou?J,?Sun?L,?Wei?ZY,?Gao?JY,?Gong?WM,?Xu?RM,?Rao?ZH,?Liu?YF*.?Structural?basis?for?the?function?of?DCN-1?in?protein?neddylation.J?BIOL?CHEM,?282(34):?24490-24494?(2007).(*?Correspondence)

Yingfang?Liu,?Adhar?C.?manna,?Cheol-Ho?Pan,?Irina?A.?Kriksunov,?Daniel?J.?Thiel,?Ambrose?L.?Cheung,?and?Gongyi?Zhang.?Structural?and?function?analyses?of?the?global?regulatory?protein?SarA?from?Staphylococcus?aureus.?Proc?Natl?Acad?Sci?USA?103:2392-7?(2006).

Yingfang?Liu?,?Xia?Hong,?John?Kappler,?Ling?Jiang,?Rongguang?Zhang,?Liangguo?Xu,?Cheol-Ho?Pan,?Hong-Bing?Shu,?Shaodong?Dai,?and?Gongyi?Zhang.?Complex?Structures?of?sTALL-1/BCMA?and?sTALL-1/BAFFR?Extracellular?Domain?Show?Unique?Ligand/Receptor?Interaction?of?TNF?Family?Members.?Nature?423,?49–?56?(2003).

Yingfang?Liu,?Liangguo?Xu,?Natasha?Opalka,?Hongbin?Shu?and?Gongyi?Zhang.?Crystal?structure?of?s-TALL1?reveals?a?novel?virus-like?assembly?of?TNF?family?ligands.?Cell?108,?383-394?(2002).

Yingfang?Liu,?Adhar?Manna,?Ronggui?Li,?Wesley?E.?Martin,?Robert?C.?Murphy,?Ambrose?L.?Cheung,?and?Gongyi?Zhang.?Crystal?structure?of?the?SarR?protein?from?Staphylococcus?aureus.?PROC?NATL?ACAD?SCI?USA?98:?6877-6882?(2001).

Yingfang?Liu,?Ruanbao?Zhou?and?Jindong?Zhao.?Molecular?cloning?and?sequencing?of?the?sodB?gene?from?a?heterocystous?cyanobacterium?Anabaena?sp.?PCC?7120.?BBA-GENE?STRUCT?EXPR,?1491,?248-252?(2000).

Yingfang?Liu,?Jingchu?Luo,?Chunyu?Xu,?Fucheng?Ren,?Cheng?Peng,?Guangyao?Wu,?and?Jindong?Zhao.?Purification,?characterization,?and?molecular?cloning?of?the?gene?of?a?seed-Specific?antimicrobial?protein?from?pokeweed.?PLANT?PHYSIOL?122,?1015-1024?(2000).